FITC标记的细胞膜蛋白Derlin抗体
产品名称： FITC标记的细胞膜蛋白Derlin抗体
英文名称： Anti-DERLIN-1/FITC
产品编号： HZ-11268R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-DERLIN-1/FITC Conjugated antibody
FITC标记的细胞膜蛋白Derlin抗体
| 产品编号 | bs-11268R-FITC |
| 英文名称 | Anti-DERLIN-1/FITC |
| 中文名称 | FITC标记的细胞膜蛋白Derlin抗体 |
| 别 名 | Derlin1; Derlin1; Derlin 1; DER1; DER-1; DER 1; DERL1_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 细胞膜蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 29kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human DERLIN-1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Degradation in endoplasmic reticulum proteins, also designated Derlins or DERtrins, are crucial for the degradation of misfolded endoplasmic reticulum (ER) luminal proteins. Derlin proteins are multi-pass membrane proteins localizing to the ER. Derlins are involved in transferring misfolded proteins from the ER to the cytosol, where the misfolded proteins are destroyed in an ubiquitin-dependent manner by the proteasome. In the case of cytomegalovirus infection, Derlin-1, as opposed to Derlins-2 and -3, is involved in the export of MHC class I heavy chains from the ER via its interaction with the viral protein US11. Derlins may also be important for cell proliferation. Function: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. In case of infection by cytomegaloviruses, it plays a central role in the export from the ER and subsequent degradation of MHC class I heavy chains via its interaction with US11 viral protein, which recognizes and associates with MHC class I heavy chains. Also participates in the degradation process of misfolded cytomegalovirus US2 protein. Subunit: Forms homo- and heterooligomers with DERL2 and DERL3; binding to DERL3 is poorer than that between DERL2 and DERL3. Interacts with AMFR, VIMP/SELS, SEL1L, SYVN1 and VCP, as well as with SEL1L-SYVN1 and VCP-VIMP protein complexes; this interaction is weaker than that observed between DERL2 and these complexes. Interacts with the cytomegalovirus US11 protein. Interacts with NGLY1 and YOD1. Does not bind to EDEM1. Interacts with RNF103. Subcellular Location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Tissue Specificity: Ubiquitous. Similarity: Belongs to the derlin family. Database links: Entrez Gene: 420350 Chicken Entrez Gene: 404121 Cow Entrez Gene: 475086 Dog Entrez Gene: 79139 Human Entrez Gene: 67819 Mouse Entrez Gene: 100626802 Pig Entrez Gene: 362912 Rat Omim: 608813 Human SwissProt: Q71SS4 Cow SwissProt: Q9BUN8 Human SwissProt: Q99J56 Mouse Unigene: 241576 Human Unigene: 289387 Mouse Unigene: 110990 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
内质网蛋白的降解，也称为DERLIN或DERTRAIN，是错误折叠内质网（ER）管腔蛋白降解的关键。Delin蛋白是多向膜蛋白，定位于ER。DurLIs涉及将错误折叠的蛋白质从ER转移到细胞质，其中错误折叠的蛋白被蛋白酶体以泛素依赖的方式破坏。在巨细胞病毒感染的情况下，DeLIL-1与DeLNS-2和3相反，参与了通过与病毒蛋白U11的相互作用从ER中导出MHC I类重链。DurLIs对细胞增殖也很重要。