分子量:36.8 kDa

纯度:>98% as determined by SDS-PAGE.

内毒素:Less than 1.0 EU per μg of the Human Annexin A5, His Tag by the LAL method.

Buffer:PBS, pH7.4

生物活性:

产品特性:Human Annexin A5, His Tag is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 36.8 kDa. The predicted N-terminus is Met 1. The reducing (R) protein migrates as 36.8 kDa in SDS-PAGE .

产品背景:Anexin A5 is a phospholipid binding protein, which binds with high affinity and selectivity to PS in the presence of calcium. PS is predominantly located in membrane leaflets, which face the cytosol. However, recent findings show that each cell type has the molecular machinery to expose PS at its cell surface. This machinery is activated during the execution of apoptosis. Once PS is exposed at the cell surface it exhibits procoagulant and proinflammatory activities. Anexin A5 will bind to the PS-exposing apoptotic cell and can inhibit the procoagulant and proinflammatory activities of the dying cell. Anexin A5  has also been identified as an anticoagulant protein in the blood coagulation cascade, by acting as an inhibitor of prothrombin activation. The presence of antibodies to Anexin A5 is associated with systemic lupus erythematosus (SLE), recurrent spontaneous abortions and systemic sclerosis (SSc).