MAPK13/SAPK4,丝裂原活化蛋白激酶13抗体

产品编号HZ-7920R
英文名称MAPK13/SAPK4
中文名称丝裂原活化蛋白激酶13抗体
别 名MAP kinase 13; MAP kinase p38 delta; MAPK 13; MGC99536; Mitogen activated protein kinase 13; Mitogen activated protein kinase p38 delta; Mitogen-activated protein kinase 13; Mitogen-activated protein kinase p38 delta; MK13_HUMAN; p38 delta; p38delta; PRKM13; Protein kinase mitogen activated 13; SAPK 4; Stress activated protein kinase 4; Stress-activated protein kinase 4.
说 明 书0.1ml 0.2ml
研究领域细胞生物 免疫学 信号转导 细胞周期蛋白 转录调节因子 激酶和磷酸酶
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Cow, Rabbit, Sheep,
MAPK13/SAPK4,丝裂原活化蛋白激酶13抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量42kDa
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human MAPK13/SAPK4
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
MAPK13/SAPK4,丝裂原活化蛋白激酶13抗体PubMedPubMed
产品介绍background:
Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating downstream targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K.
Tissue specificity:Expressed in testes, pancreas, small intestine, lung and kidney. Abundant in macrophages, also present in neutrophils, CD4+ T-cells, and endothelial cells.

Function:
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studied p38 MAPK isoforms. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K. Involved in cytoskeletal remodeling through phosphorylation of MAPT and STMN1. Mediates UV irradiation induced up-regulation of the gene expression of CXCL14. Plays an important role in the regulation of epidermal keratinocyte differentiation, apoptosis and skin tumor development. Phosphorylates the transcriptional activator MYB in response to stress which leads to rapid MYB degradation via a proteasome-dependent pathway. MAPK13 also phosphorylates and down-regulates PRKD1 during regulation of insulin secretion in pancreatic beta cells.

MAPK13/SAPK4,丝裂原活化蛋白激酶13抗体Subunit:
Interacts with MAPK8IP2.

Tissue Specificity:
Expressed in testes, pancreas, small intestine, lung and kidney. Abundant in macrophages, also present in neutrophils, CD4+ T-cells, and endothelial cells.

Post-translational modifications:
Dually phosphorylated on Thr-180 and Tyr-182 by MAP2K3/MKK3, MAP2K4/MKK4, MAP2K6/MKK6 and MAP2K7/MKK7, which activates the enzyme. Dephosphorylated by dual specificity phosphatase DUSP1.

Similarity:
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
Contains 1 protein kinase domain.

Gene ID:
5603

Database links:
Entrez Gene: 5603 Human
Entrez Gene: 26415 Mouse
Entrez Gene: 29513 Rat
Omim: 602899 Human
SwissProt: O15264 Human
SwissProt: Q9Z1B7 Mouse
SwissProt: Q9WTY9 Rat
Unigene: 178695 Human
Unigene: 27970 Mouse
Unigene: 207195 Rat

MAPK13/SAPK4,丝裂原活化蛋白激酶13抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.