Transglutaminase 2,谷氨酰胺转胺酶2抗体

产品编号HZ-8589R
英文名称Transglutaminase 2
中文名称谷氨酰胺转胺酶2抗体
别 名TG 2; TG(C); TG2; TGase C; TGase H; TGase-2; TGase2; TgaseII; ALPHA SUBUNIT; C polypeptide; G alpha h; G protein alpha subunit Gh class; G[a]h; Gh CLASS G ALPHA h; GNAH; GNAH G PROTEIN; Guanine nucleotide binding protein H polypeptide; H POLYPEPTIDE; Protein glutamine gamma glutamyltransferase 2; Protein glutamine gamma glutamyltransferase; Protein-glutamine gamma-glutamyltransferase 2; TGC; TGC GUANINE NUCLEOTIDE BINDING PROTEIN; TGM 2; TGM2; TGM2_HUMAN; Tissue transglutaminase; Tissue type transglutaminase; Transglutaminase 2; Transglutaminase 2 C polypeptide; Transglutaminase C; Transglutaminase H; Transglutaminase-2; tTG; tTGas.
说 明 书0.1ml 0.2ml
研究领域肿瘤 细胞生物 信号转导 转录调节因子
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
Transglutaminase 2,谷氨酰胺转胺酶2抗体产品应用ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量77kDa
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Transglutaminase 2
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Transglutaminase 2,谷氨酰胺转胺酶2抗体PubMedPubMed
产品介绍background:
Terminally differentiating mammalian epidermal cells acquire an insoluble, 10 to 20 nm thick protein deposit on the intracellular surface of the plasma membrane known as the cross-linked cell envelope (CE). The CE is a component of the epidermis that is generated through formation of disulfide bonds and g-glutamyl-lysine isodipeptide bonds, which are formed by the action of transglutaminases (TGases). TGases are intercellularly localizing, Ca2+-dependent enzymes that catalyze the formation of isopeptide bonds by transferring an amine on to glutaminyl residues, thereby cross-linking glutamine residues and lysine residues in substrate proteins. TGases influence numerous biological processes, including blood coagulation, epidermal differentiation, seminal fluid coagulation, fertilization, cell differentiation and apoptosis. Human keratinocyte transglutaminase (TGase1) is a membrane associated, 817 amino acid protein. Human tissue transglutaminase (TGase2) is an endothelial cell specific, 687 amino acid protein.

Function:
Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.

Subunit:
Monomer.

Similarity:
Belongs to the transglutaminase superfamily. Transglutaminase family.

Database links:
Entrez Gene: 7052 Human
Entrez Gene: 21817 Mouse
Omim: 190196 Human
SwissProt: P21980 Human
SwissProt: P21981 Mouse
Unigene: 517033 Human
Unigene: 330731 Mouse

Transglutaminase 2,谷氨酰胺转胺酶2抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.