Reg3 beta,胰岛β细胞生长因子Reg IIIα 抗体

产品编号HZ-4911R
英文名称Reg3 beta
中文名称胰岛β细胞生长因子Reg IIIα 抗体
别 名Pap; Pap1; REG3B_MOUSE; Regenerating islet-derived protein 3-beta; REG-3-beta; Pancreatitis-associated protein 1; Regenerating islet-derived protein III-beta; Reg III-beta.
说 明 书0.1ml 0.2ml
研究领域肿瘤 细胞生物 免疫学 信号转导
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Mouse, Rat,
Reg3 beta,胰岛β细胞生长因子Reg IIIα 抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量16kDa
细胞定位分泌型蛋白
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from mouse Reg3 beta
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Reg3 beta,胰岛β细胞生长因子Reg IIIα 抗体PubMedPubMed
产品介绍background:
The regeneration (REG) family consists of secretory proteins involved in liver, pancreatic, gastric and intestinal cell proliferation or differentiation. Members of the REG family are divided into four subclasses, designated types I, II, III and IV. They have been implicated in the regulation of cell growth, tumorigenesis and the progression of cancer. Specifically, increased expression of Reg III Alpha results in pancreatic inflammation and liver carcinogenesis. Reg III Alpha, also de-signated pancreatitis-associated protein, localizes to the apical region of pancreatic acinar cells and is similar to the C-type lectin superfamily. The Reg III Alpha protein is mainly expressed in the intestine, with lower expression detected in healthy pancreas. It is also detected in pancreatic juice as a result of pancreatic inflammation.

Function:
Might be a stress protein involved in the control of bacterial proliferation.

Subcellular Location:
Secreted. Found in the apical region of pancreatic acinar cells.

Tissue Specificity:
Constitutively expressed in the small intestine, moderately in colon and at an extremely low level in healthy pancreas.

DISEASE:
Note=Overexpressed during the acute phase of pancreatitis.

Reg3 beta,胰岛β细胞生长因子Reg IIIα 抗体Similarity:
Contains 1 C-type lectin domain.

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.