Connexin-45,间隙连接蛋白45抗体

产品编号HZ-0652R
英文名称Connexin-45
中文名称间隙连接蛋白45抗体
别 名Connexin 45; Connexin45; Connexin-45; CX 31.9; CX 45; CX31.9; CX45; DKFZp686P0738; Gap junction alpha 7 protein; Gap junction alpha-7 protein; Gap junction protein alpha 7 45kDa; Gap junction protein alpha 7; Gap junction protein, gamma 1, 45kDa; GJA 7; GJA7; GJD3; Gap junction gamma-1 protein; CXG1_HUMAN.
说 明 书0.1ml 0.2ml
研究领域心血管 信号转导 细胞粘附分子
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog, Pig,
Connexin-45,间隙连接蛋白45抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量45kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Connexin-45 (81-130aa)
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Connexin-45,间隙连接蛋白45抗体PubMedPubMed
产品介绍background:
This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. The encoded protein is the major protein of gap junctions in the heart that are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. A related intronless pseudogene has been mapped to chromosome 5. Mutations in this gene have been associated with oculodentodigital dysplasia and heart malformations.

Function:
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. A connexon is composed of a hexamer of connexins.

Subunit:
A connexon is composed of a hexamer of connexins. Interacts with CNST.

Subcellular Location:
Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.

Similarity:
Belongs to the connexin family. Gamma-type subfamily.

Gene ID:
10052

Connexin-45,间隙连接蛋白45抗体Database links:
Entrez Gene: 10052 Human
Entrez Gene: 14615 Mouse
Entrez Gene: 266706 Rat
Omim: 608655 Human
SwissProt: P36383 Human
SwissProt: P28229 Mouse
SwissProt: A4GVD1 Pig
SwissProt: A4GG66 Rat
Unigene: 195419 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

通道蛋白（Channel Protein）
Connexin45又称缝隙连接膜通道蛋白alpha7，Cx45构成细胞间的通道,小分子成份可以借此在细胞间扩散。
Connexin-45是心肌缝隙连接蛋白的主要蛋白之一。

产品图片