PMCA1,细胞膜钙ATP酶1抗体

产品编号HZ-6443R
英文名称PMCA1
中文名称细胞膜钙ATP酶1抗体
别 名AT2B1_HUMAN; ATP2B1; ATPase Ca++ transporting plasma membrane 1; Plasma membrane calcium ATPase 1; Plasma membrane calcium ATPase isoform 1; Plasma membrane calcium pump isoform 1; Plasma membrane calcium transporting ATPase 1; Plasma membrane calcium-transporting ATPase 1; PMCA 1; PMCA1.
说 明 书0.1ml 0.2ml
研究领域肿瘤 细胞生物 免疫学 神经生物学 信号转导 转录调节因子
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
PMCA1,细胞膜钙ATP酶1抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:20-200 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量138kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human PMCA1
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PMCA1,细胞膜钙ATP酶1抗体PubMedPubMed
产品介绍background:
Plasma membrane-type Ca2+-ATPases (PMCAs) mediate the export of bivalent calcium ions from eukaryotic cells. As members of the P class of ion-motive ATPases, PMCAs are a functionally diverse group of proteins that are derived from alternatively spliced transcripts originating from at least four distinct genes. The expression of different PMCA isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, and with respect to the physiological needs of specific cell and tissue types. Spatial and temporal rates of resting intracellular Ca2+ concentrations and Ca2+ signaling in eukaryotic cells are dependent on the array of PMCA isoforms that are expressed in concert with the rate of Ca2+ export. PMCA1 (ATP2B1) is a ubiquitously expressed form of the PMCA calcium exporter family.

Function:
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell.

Subcellular Location:
Cell membrane. Multi-pass membrane protein.

Tissue Specificity:
Isoform B is ubiquitously expressed. Isoform C is found in brain cortex, skeletal muscle and heart muscle. Isoform D has only been found in fetal skeletal muscle. Isoform K has been found in small intestine and liver.

PMCA1,细胞膜钙ATP酶1抗体Similarity:
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.

Database links:
UniProtKB/Swiss-Prot: P20020.3

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.