IL1R1 (phospho Y496) polyclonal antibody
产品名称： IL1R1 (phospho Y496) polyclonal antibody
英文名称： IL1R1 (phospho Y496) polyclonal antibody
产品编号： PAB0494
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic phosphopeptide of IL1R1.
- Immunogen:
- Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding Y496 of human IL1R1.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2.
Debets R, Timans JC, Homey B, Zurawski S, Sana TR, Lo S, Wagner J, Edwards G, Clifford T, Menon S, Bazan JF, Kastelein RA.J Immunol. 2001 Aug 1;167(3):1440-6.
- 2.
- Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q.
Dale M, Nicklin MJ.Genomics. 1999 Apr 1;57(1):177-9.
- 3.
- Purification and characterization of the human interleukin-18 receptor.
Torigoe K, Ushio S, Okura T, Kobayashi S, Taniai M, Kunikata T, Murakami T, Sanou O, Kojima H, Fujii M, Ohta T, Ikeda M, Ikegami H, Kurimoto M.J Biol Chem. 1997 Oct 10;272(41):25737-42.
- Applications
- Western Blot (Tissue lysate)
- IL1R1 (phospho Y496) polyclonal antibody (Cat # PAB0494). Western blot analysis of IL1R1 expression in human liver.
- Protocol Download
- Western Blot (Tissue lysate)
- The IL1R1 (phospho Y496) polyclonal antibody (Cat # PAB0494) is used in Western blot to detect Phospho-IL1R1-Y496 in mouse liver tissue lysate.
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human cancer tissue reacted with IL1R1 (phospho Y496) polyclonal antibody (Cat # PAB0494) which was peroxidase-conjugated to the secondary antibody followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma.
- Entrez GeneID:
- 3554
- Protein Accession#:
- NP_000868;P14778
- Gene Name:
- IL1R1
- Gene Alias:
- CD121A,D2S1473,IL-1R-alpha,IL1R,IL1RA,P80
- Gene Description:
- interleukin 1 receptor, type I
- Omim ID:
- 147810
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein is a receptor for interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA). It is an important mediator involved in many cytokine induced immune and inflammatory responses. This gene along with interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 2 (IL1RL2), and interleukin 1 receptor-like 1 (IL1RL1) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. [provided by RefSeq
- Other Designations:
- OTTHUMP00000161344,antigen CD121a,interleukin 1 receptor alpha, type I,interleukin receptor 1
- Related Disease
- Acquired Immunodeficiency Syndrome
- Acute Disease
- Albuminuria
- Alcoholism
- Alveolar Bone Loss
- Alveolitis, Extrinsic Allergic
- Alzheimer Disease
- Alzheimer disease
- Anemia
- Arthritis, Juvenile Rheumatoid
- Arthritis, Psoriatic
- Arthritis, Rheumatoid
- Asthma
- Asthma
- Atherosclerosis
- Atherosclerosis
- Bone Resorption
- Brain Ischemia
- Bronchiolitis, Viral