FITC标记的载脂蛋白C1抗体
产品名称： FITC标记的载脂蛋白C1抗体
英文名称： Anti-Apolipoprotein CI/APOC1/FITC
产品编号： HZ-12496R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-Apolipoprotein CI/APOC1/FITC Conjugated antibody
FITC标记的载脂蛋白C1抗体
| 英文名称 | Anti-Apolipoprotein CI/APOC1/FITC |
| 中文名称 | FITC标记的载脂蛋白C1抗体 |
| 别 名 | APO C1; Apo CI; Apo-CIB; Apo-CIB'; apoC-I ; APOC 1; ApoC I; ApoC-IB; ApoC-IB'; APOC1; APOC1B; Apolipoprotein C I; Apolipoprotein C-I; Apolipoprotein CI; ApolipoproteinC I; ApolipoproteinCI; Truncated apolipoprotein C-I; APOC1_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 信号转导 新陈代谢 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 7kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Apolipoprotein CI/APOC1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Apolipoproteins are protein components of plasma lipoproteins. The apolipoprotein C gene family encodes four homologous proteins designated apoC-I to -IV, which specifically modulate the metabolism of triglyceride-rich lipoproteins. The human apoC-I gene maps to chromosome 19q13.2 and is expressed primarily in the liver where it is activated when monocytes differentiate into macrophages. The human apoC-II gene maps to chromosome 19q13.2 and encodes a 79 amino acid single chain protein that is a necessary cofactor for the activation of lipoprotein lipase, the enzyme that hydrolyzes triglycerides in plasma and transfers the fatty acids to tissues. The human apoC-III gene maps to chromosome 11q23 and encodes a protein that may delay catabolism of triglyceride-rich particles by inhibiting lipoprotein lipase and hepatic lipase. The human apoC-IV gene maps to chromosome 19q13.2 and encodes a 127 amino acid protein that is primarily expressed in the liver. Function: The protein encoded by this gene is a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within a apolipoprotein gene cluster. Alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. Apolipoprotein C-I appears to modulate the interaction of APOE with beta migrating VLDL and inhibit binding of beta VLDL to the LDL receptor related protein. At least 9 distinct polymorphic forms of apolipoproteins are known. The apolipoproteins act as stabilizers of the intact lipoprotein particles. Quantitative measurements of HDL, LDL and VLDL particles in human serum are often used to estimate an individuals' relative risk of coronary heart disease. In addition, quantitative immunological measurements of certain apolipoproteins (especially A1 and B) have been suggested to be more accurate estimators of coronary heart disease than measurements of lipoprotein particles (especially HDL and LDL). Subcellular Location: Secreted Tissue Specificity: Synthesized mainly in liver and to a minor degree in intestine. Secreted in plasma. Similarity: Belongs to the apolipoprotein C1 family. Database links: UniProtKB/Swiss-Prot: P02654.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
载脂蛋白是血浆脂蛋白的蛋白质组分。载脂蛋白C基因家族编码4个同源蛋白，命名为apoC-I至-IV，它们特异性地调节富含甘油三酯的脂蛋白的代谢。人载脂蛋白C-I基因定位于染色体19q13.2，主要表达在肝脏，当单核细胞分化为巨噬细胞时，它被激活。人载脂蛋白C-II基因定位于染色体19q13.2，编码79个氨基酸的单链蛋白，它是脂蛋白脂酶激活的必要辅助因子，脂蛋白脂酶是水解血浆中的甘油三酯并将脂肪酸转移到组织的酶。人载脂蛋白C-III基因定位于染色体11q23，编码一种蛋白质，该蛋白质可能通过抑制脂蛋白脂肪酶和肝脂肪酶而延迟富含甘油三酯的颗粒的分解代谢。人类APCO-IV基因映射到染色体19q132，并编码主要在肝脏中表达的127个氨基酸蛋白。