分子量:32 kDa

纯度:>95% as determined by SDS-PAGE.

内毒素:Less than 1.0 EU per μg of the Human BCMA, Fc Tag by the LAL method.

Buffer:50 mM tris, 100 mM glycine, pH7.5

生物活性:Measured by its binding ability in a functional ELISA. Immobilized recombinant human BAFF at 1 μg/mL ( 100 μl/well ) can bind Human BCMA, Fc Tag. The EC50 of human TNFRSF17 is 0.08 μg/mL

产品特性:Human BCMA, Fc Tag is fused with a human IgG1 Fc tag at the C-terminus, and has a calculated MW of 32 kDa. The predicted N-terminus is Met 1. As a result of glycosylation, the reducing (R) protein migrates as 35-40 kDa, and the non-reducing (NR) protein migrates as 66 kDa in SDS-PAGE .

产品背景:Tumor necrosis factor receptor superfamily member 17 (TNFRSF17) is also known as B-cell maturation protein (BCMA), CD antigen CD269, which is a member of the TNF-receptor superfamily. TNFRSF17 contains one TNFR-Cys repeat. TNFRSF17 is expressed in mature B-cells, but not in T-cells or monocytes. TNFRSF17 is receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. TNFRSF17 promotes B-cell survival and plays a role in the regulation of humoral immunity. TNFRSF17 can activate NF-kappa-B and JNK.