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上海信裕生物科技有限公司
APPL1抗体

APPL1抗体

商家询价

产品名称： APPL1抗体

英文名称： APPL1Antibody

产品编号： XY12639-1

产品价格： null

产品产地： 中国/美国

品牌商标： XYbscience

更新时间： 2023-08-17T09:55:27

使用范围： WB,ELISA,IHC-P,IHC-F,IF

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 APPL1抗体

Applications
In-house applications ELISA, WB, IHC, IP     Application not tested? Please see our Guarantee.
Published applications IF, IHC, WB Publications 2 citations –view here
Species specificity Human,Mouse,Rat; other species not tested.
Published Species Human
Images
Prev1NextView more validation data
  • 12639-1-AP;human brain tissuehuman brain tissue were subjected to SDS PAGE followed by western blot with 12639-1-AP(APPL1 antibody) at dilution of 1:500
  • 12639-1-AP;human ovary tumorImmunohistochemical of paraffin-embedded human ovary tumor using 12639-1-AP(APPL1 antibody) at dilution of 1:50 (under 10x lens)
  • 12639-1-AP;mouse brain tissueIP Result of anti-APPL1 (IP:12639-1-AP, 4ug; Detection:12639-1-AP 1:500) with mouse brain tissue lysate 4000ug.
Positive WB detected in Human brain tissue, mouse ovary tissue
Positive IP detected in Mouse brain tissue
Positive IHC detected in Human ovary tumor tissue
Recommended dilution WB : 1:500-1:5000
IP : 1:200-1:2000
IHC : 1:20-1:200
 APPL1抗体Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
Product Information
Source Rabbit Purification method Antigen affinity purification
Isotype IgG Storage PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC.
Immunogen Information APPL1抗体
Immunogen APPL1 fusion protein ag3334 Full name Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
Calculated molecular
weight		 709aa,80 kDa Observed molecular 
weight		 80kd
GenBank accession 
number		 BC028599 Gene ID (NCBI) 26060
Gene symbol APPL1 Synonyms APPL, APPL1, Dip13 alpha, DIP13A, DIP13alpha, KIAA1428
Background

Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 (APPL1), a binding partner of Akt2 and an important regulator of insulin signaling, plays a key role in the regulation of insulin secretion [PMID:22615370]. APPL1 interacts with adiponectin receptors and mediates the insulin-sensitizing effects of adiponectin in muscle and endothelial cells. It also participates in nuclear signaling and transcriptional regulation, mostly by modulating the activity of various nuclear factors [PMID:22685329]. Apart from its role in endocytosis and endosomal transport, APPL1 was reported to undergo nucleocytoplasmic shuttling and participate in transcriptional regulation, e.g. by interactions with histone deacetylases (HDACs) [PMID:19686092]. APPL1抗体

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