NEDD1,神经前体细胞表达蛋白1抗体

产品编号HZ-7813R
英文名称NEDD1
中文名称神经前体细胞表达蛋白1抗体
别 名GCP WD; Neural precursor cell expressed, developmentally down regulated gene 1; TUBGCP7; FLJ35902; NEDD1_HUMAN.
说 明 书0.1ml 0.2ml
研究领域细胞生物 神经生物学 干细胞 细胞周期蛋白 表观遗传学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Cow, Rabbit,
NEDD1,神经前体细胞表达蛋白1抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量72kDa
细胞定位细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human NEDD1
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
NEDD1,神经前体细胞表达蛋白1抗体PubMedPubMed
产品介绍background:
May play an important role during the embryonic development and differentiation of the central nervous system. Human NEDD1 localises to the centrosome and mitotic spindle. It binds to the components of the gamma-tubulin ring complex and target this complex to the centrosome and spindle.

Function:
Required for mitosis progression. Promotes thenucleation of microtubules from the spindle.

Subunit:
Interacts with FAM29A and gamma-tubulin.

Subcellular Location:
Cytoplasm, cytoskeleton, centrosome.

Post-translational modifications:
During mitosis, prior phosphorylation on Thr-550 by CDK1promotes subsequent phosphorylation by PLK1 on Thr-382, Ser-397,Ser-426 and Ser-637. Phosphorylated NEDD1 can interact withgamma-tubulin for targeting the gamma-tubulin ring complex (gTuRC)to the centrosome, an important step for spindle formation.

NEDD1,神经前体细胞表达蛋白1抗体Similarity:
Contains 8 WD repeats.

Database links:
UniProtKB/Swiss-Prot: Q8NHV4.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.