NHEDC2,线粒体钠/氢交换蛋白质2抗体

产品编号HZ-9712R
英文名称NHEDC2
中文名称线粒体钠/氢交换蛋白质2抗体
别 名NHA2; Mitochondrial Na(+)/H(+) exchanger NHA2; Mitochondrial sodium/hydrogen exchanger NHA2; Na(+)/H(+) exchanger like domain containing protein 2; Na+/H+ exchanger domain containing 2; NHE domain containing protein 2; NHE10; NHEDC 2; Sodium/hydrogen exchanger like domain containing protein 2; SL9B2_HUMAN.
说 明 书0.1ml 0.2ml
研究领域细胞生物 信号转导 细胞周期蛋白 细胞分化 细胞骨架 细胞外基质
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Rabbit,
NHEDC2,线粒体钠/氢交换蛋白质2抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量58kDa
细胞定位细胞浆 细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human NHEDC2
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
NHEDC2,线粒体钠/氢交换蛋白质2抗体PubMedPubMed
产品介绍background:
Na+/H+ exchangers (NHEs) catalyze the transport of Na+ in exchange for H+ across membranes in organisms and are required for numerous physiological processes. NHEDC2 (Na+/H+ exchanger-like domain-containing protein 2), also known as NHA2, is a 537 amino acid mitochondrial protein. NHEDC2 is involved in organelle volume homeostasis by catalyzing the exchange of protons for Na+ and Li+ across the inner mitochondrial membrane. Found in red blood cells, NHEDC2 is required for bone resorption activity and osteoclast differentiation. As a multi-pass membrane protein, NHEDC2 is expressed as two isoforms produced by alternative splicing events.

Function:
Electroneutral exchange of protons for Na(+) and Li(+)across the inner mitochondrial membrane. Contributes to theorganellar volume homeostasis. Required for osteoclastdifferentiation and bone resorption activity (By similarity).

Subcellular Location:
Mitochondrion membrane; Multi-pass membraneprotein (By similarity).

Tissue Specificity:
Detected in red blood cells (at proteinlevel).

Similarity:
Belongs to the monovalent cation:proton antiporter 1(CPA1) transporter (TC 2.A.36) family.

Database links:
Entrez Gene: 133308 Human
Entrez Gene: 97086 Mouse
Entrez Gene: 365946 Rat
Omim: 611789 Human
SwissProt: Q86UD5 Human
SwissProt: Q5BKR2 Mouse
Unigene: 546482 Human
Unigene: 441764 Mouse

NHEDC2,线粒体钠/氢交换蛋白质2抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.