内毒素:
Less than 1.0 EU per μg by the LAL method.

纯度:
>95% as determined by SDS-PAGE.

活性:
Measured by its binding ability in a functional ELISA. Immobilized Human IL-17A, Tag Free (Catalog # ILA-H5118) at 2μg/mL (100 μL/well) can bind Biotinylated Human IL-17 RA, Fc Tag (Catalog # ILA-H82F1) with a linear range of 1.2-9.8 ng/mL.

产品背景:
Interleukin 17 receptor A (IL17RA) is also known as cluster of differentiation w217 (CDw217), is a pro-inflammatory cytokine secreted by activated T-lymphocytes, belong to ubiquitous type I membrane glycoprotein, and binds with low affinity to interleukin 17A (IL17A). IL 17R mRNA exhibits a broad tissue distribution, and has been detected in virtually all cells and tissues tested . IL 17RA associates with IL 17RC to form a signaling receptor complex for IL 17 and IL 17F . Ligand and IL 17RA ligation promotes T cell activation and the production of IL - 6, G-CSF, SCF, and multiple pro-inflammatory chemokines. Defects in IL17RA are the cause of familial candidiasis type 5 (CANDF5).

产品描述:
This protein carries a human IgG1 Fc tag at the C-terminus, followed by a Avi tag (Avitag). The protein has a calculated MW of 61.9 kDa. As a result of glycosylation, The protein migrates as 80-115 kDa under reducing (R) condition and 150-200 kDa under non-reducing (NR) condition on SDS-PAGE gel.