CDC37,Hsp90辅助伴侣分子CDC37抗体

产品编号HZ-4290R
英文名称CDC37
中文名称Hsp90辅助伴侣分子CDC37抗体
别 名S cerevisiae hypothetical protein CDC37; CDC 37; CDC37; CDC37 cell division cycle 37 homolog; CDC37 cell division cycle 37 S cerevisiae homolog; Cdc37 homolog; CDC37 protein; CDC37_HUMAN; CDC37A; Cell division cycle 37 homolog; Hsp90 chaperone protein kinase targeting subunit; Hsp90 chaperone protein kinase targeting subunit p50Cdc37; Hsp90 chaperone protein kinase-targeting subunit; Hsp90 co chaperone Cdc37; Hsp90 co-chaperone Cdc37; p50; p50Cdc37.
说 明 书0.1ml 0.2ml
研究领域细胞生物 信号转导 细胞周期蛋白 激酶和磷酸酶 表观遗传学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog, Pig, Cow,
CDC37,Hsp90辅助伴侣分子CDC37抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量42kDa
细胞定位细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human CDC37
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
CDC37,Hsp90辅助伴侣分子CDC37抗体PubMedPubMed
产品介绍background:
Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity.

Function:
Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity.

Subunit:
Forms a complex with Hsp90/HSP90AB1 and CDK6. Interacts with AR, CDK4, CDK6, EIF2AK1 and RB1.

Subcellular Location:
Cytoplasm.

Post-translational modifications:
Constitutively sumoylated by UBE2I.

Similarity:
Belongs to the CDC37 family.

Gene ID:
11140

Database links:
Entrez Gene: 38232 Fruit fly (Drosophila melanogaster)
Entrez Gene: 11140 Human
Entrez Gene: 12539 Mouse
Entrez Gene: 114562 Rat
Omim: 605065 Human
SwissProt: Q24276 Fruit fly (Drosophila melanogaster)
SwissProt: Q16543 Human
SwissProt: Q61081 Mouse
SwissProt: Q63692 Rat
Unigene: 4857 Fruit fly (Drosophila melanogaster)
Unigene: 160958 Human
Unigene: 32331 Mouse
Unigene: 17982 Rat

CDC37,Hsp90辅助伴侣分子CDC37抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品图片

Tissue/cell: Rat brain; 4% Paraformaldehyde-fixed and paraffin-embedded;  Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;  Incubation: Anti-CDC37 Polyclonal Antibody, Unconjugated(HZ-4290R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining Tissue/cell: Human lung carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded;  Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;  Incubation: Anti-CDC37 Polyclonal Antibody, Unconjugated(HZ-4290R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining