ABI2,肿瘤抑制基因ABI2/精氨酸酪氨酸蛋白激酶结合蛋白抗体

产品编号HZ-5984R
英文名称ABI2
中文名称肿瘤抑制基因ABI2/精氨酸酪氨酸蛋白激酶结合蛋白抗体
别 名Abelson interactor 2; ABI 2; ABI2B; Abl binding protein 3; Abl interacting protein 1 (SH3 containing protein); Abl interactor 2; Abl interactor protein 2b; AblBP3; AIP 1; Arg binding protein 1; Arg protein tyrosine kinase binding protein; ArgBP1; ARGBPIA; ArgBPIB; SSH3BP2; ABI2_HUMAN.
规格价格0.1ml 0.2ml 
说 明 书0.1ml 0.2ml
研究领域肿瘤 免疫学 激酶和磷酸酶
抗体来源Rabbit
克隆类型Polyclonal
ABI2,肿瘤抑制基因ABI2/精氨酸酪氨酸蛋白激酶结合蛋白抗体交叉反应Human, Mouse, Rat, Chicken, Dog, Pig, Horse, Rabbit, Sheep,
产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量56kDa
细胞定位细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human ABI2
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
ABI2,肿瘤抑制基因ABI2/精氨酸酪氨酸蛋白激酶结合蛋白抗体PubMedPubMed
产品介绍background:
ABI2 (Abelson interactor 2) belongs to the ABI family. The Abelson interactors are among a group of proteins that interact with Abl tyrosine kinase, a non-receptor tyrosine kinase whose activation results in the regulation of cytoskeleton function, cell growth and apoptosis in response to a variety of biological stimuli.

Function:
May act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Regulates ABL1/c-Abl-mediated phosphorylation of MENA. [SUBUNIT] Component of the WAVE1 complex composed of ABI2, CYFIP1 or CYFIP2, BRK1, NCKAP1 and WASF1/WAVE1. Within the complex, a heterdimer containing NCKAP1 and CYFIP1 interacts with a heterotrimer formed by WAVE1, ABI2 and BRK1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1 (By similarity). Interacts with ABL1 and ABL2.

Subcellular Location:
Cytoplasm (By similarity).
Isoform 1: Cell projection, lamellipodium (By similarity). Cell projection, filopodium (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=Isoform 1 but not isoform 3 is localized to protruding lamellipodia and filopodia tips (By similarity).

Post-translational modifications:
Is a substrate for ABL1.

Similarity:
Belongs to the ABI family.
Contains 1 SH3 domain.
Contains 1 t-SNARE coiled-coil homology domain.

ABI2,肿瘤抑制基因ABI2/精氨酸酪氨酸蛋白激酶结合蛋白抗体Gene ID:
10152

Database links:
Entrez Gene: 10152 Human
Entrez Gene: 329165 Mouse
Entrez Gene: 286928 Rat
Omim: 606442 Human
SwissProt: Q9NYB9 Human
SwissProt: P62484 Mouse
Unigene: 471156 Human
Unigene: 212066 Mouse
Unigene: 465571 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.