APNG/MPG,N-甲基嘌呤DNA糖基化酶

产品编号HZ-2412R
英文名称APNG/MPG
中文名称N-甲基嘌呤DNA糖基化酶
别 名MPG; N-methylpurine-DNA glycosylase isoform a; DNA 3 methyladenine glycosylase; 3 alkyladenine DNA glycosylase; AAG; ADPG; Alkyladenine DNA glycosylase; anpg ; APNG; MDG; N methylpurine DNA glycosirase; CRA36.1; MDG; Mid1; PIG11; PIG16; 3MG_HUMAN.
规格价格0.1ml 0.2ml 
说 明 书0.1ml 0.2ml
研究领域细胞生物 染色质和核信号 表观遗传学
抗体来源Rabbit
克隆类型Polyclonal
APNG/MPG,N-甲基嘌呤DNA糖基化酶交叉反应Human, Mouse, Rat, Pig, Cow,
产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量33kDa
细胞定位细胞核
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human APNG/MPG
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
APNG/MPG,N-甲基嘌呤DNA糖基化酶PubMedPubMed
产品介绍background:
MPG (N-methylpurine DNA glycosylase, or 3-methyladenine (3MeA) DNA glycosylase) repairs the 3MeA lethal lesion blocking DNA replication in Escherichia coli. Analysis of human cDNA libraries found a cDNA that would hybridize to human genomic DNA but not to E. coli or yeast DNA. This MPG gene has been mapped to human chromosome 16 by analysis of a panel of DNAs from mouse/human and hamster/human hybrid cell lines.

Function:
Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions.

Subunit:
Belongs to the DNA glycosylase MPG family.

Subcellular Location:
Nucleus.

Similarity:
Belongs to the DNA glycosylase MPG family.

Gene ID:
4350

APNG/MPG,N-甲基嘌呤DNA糖基化酶Database links:
Entrez Gene: 4350 Human
Entrez Gene: 268395 Mouse
Entrez Gene: 24561 Rat
Omim: 156565 Human
SwissProt: P29372 Human
SwissProt: Q04841 Mouse
SwissProt: P23571 Rat
Unigene: 459596 Human
Unigene: 263161 Mouse
Unigene: 482070 Mouse
Unigene: 11241 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.