EBNA 3C,EB病毒核抗原-3C抗体

产品编号HZ-14494R
英文名称EBNA 3C
中文名称EB病毒核抗原-3C抗体
别 名EBNA3C; EBNA 4B; EBNA 6; EBNA 3C; EBNA6_EBVB9; EBV; EBV nuclear antigen 6; Epstein Barr nuclear antigen 6; HHV4; Human Herpesvirus 4.
说 明 书0.1ml 0.2ml
研究领域免疫学 细菌及病毒
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human Herpesvirus 4
EBNA 3C,EB病毒核抗原-3C抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量109kDa
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human EBNA 3C
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
EBNA 3C,EB病毒核抗原-3C抗体PubMedPubMed
产品介绍background:
EBNA 3C is a latent viral nuclear protein expressed in EBV transformed lymphoblastic cell lines and is essential for EBV mediated transformation of these cell lines. This viral nuclear protein is essential for EBV mediated positive immunoblastic lymphomas, and functions as a transcription factor.

Function:
Plays an essential role for the activation and mmortalization of human B-cells. Represses transcription of viral romoters TP1 and Cp through interaction with host RBPJ, and nhibits EBNA2-mediated activation of these promoters. Since Cp is he promoter for all EBNA mRNAs, EBNA6 probably contributes to a egative autoregulatory control loop. Alternatively, EBNA6 also egulates the transcription of the EBV oncogene LMP1 in a cell ycle-dependent manner. It modulates the activity of several host roteins involved in cell cycle regulation including host cyclin A, YC, RB and p27 mainly through binding to the host SCF(SKP2) omplex.

Subunit:
Interacts with host CTPB1; this interaction seems mportant for EBNA6-mediated transcriptional repression. Interacts ith host MYC; this interaction enhances MYC stability. Interacts via N-terminus) with host RBPJ.

Subcellular Location:
Host nucleus matrix. Note=Associated with he nuclear matrix.

Post-translational modifications:

DISEASE:

EBNA 3C,EB病毒核抗原-3C抗体Similarity:
Belongs to the herpesviridae EBNA-6 family.

Database links:

UniProtKB/Swiss-Prot: P03204.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.