Liprin alpha 1,酪氨酸磷酸酶受体相互作用蛋白Liprin α1抗体

产品编号HZ-11463R
英文名称Liprin alpha 1
中文名称酪氨酸磷酸酶受体相互作用蛋白Liprin α1抗体
别 名PPFIA1; LAR interacting protein 1; LIP 1; LIP.1; LIP1; LIPRIN; MGC26800; PPFIA 1; PPFIA1; Protein tyrosine phosphatase receptor type f polypeptide (PTPRF) interacting protein (liprin) alpha 1; Protein tyrosine phosphatase receptor type f polypeptide interacting protein alpha 1; PTPRF interacting protein alpha 1; LIPA1_HUMAN.
说 明 书0.1ml 0.2ml
研究领域神经生物学 信号转导 激酶和磷酸酶
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,
Liprin alpha 1,酪氨酸磷酸酶受体相互作用蛋白Liprin α1抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量136kDa
细胞定位细胞浆 细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Liprin alpha 1 (141-190aa)
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈.
Liprin alpha 1,酪氨酸磷酸酶受体相互作用蛋白Liprin α1抗体PubMedPubMed
产品介绍background:
The protein encoded by this gene is a member of the LARprotein-tyrosine phosphatase-interacting protein (liprin) family.Liprins interact with members of LAR family of transmembraneprotein tyrosine phosphatases, which are known to be important foraxon guidance and mammary gland development. This protein binds tothe intracellular membrane-distal phosphatase domain of tyrosinephosphatase LAR, and appears to localize LAR to cell focaladhesions. This interaction may regulate the disassembly of focaladhesion and thus help orchestrate cell-matrix interactions.Alternatively spliced transcript variants encoding distinctisoforms have been described. [provided by RefSeq, Jul 2008].

Function:
This protein is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. This protein binds to the intracellular membrane-distal phosphatase domain of tyrosine phosphatase LAR, and appears to localize LAR to cell focal adhesions. This interaction may regulate the disassembly of focal adhesion and thus help orchestrate cell-matrix interactions.

Subunit:
Forms homodimers and heterodimers with liprins-alpha andliprins-beta. Interacts with the second PTPase domain of PTPRD,PTPRF and PTPRS. Interacts with GIT1, KIF1A and GRIP1

Subcellular Location:
Cytoplasm. Note=Colocalizes with PTPRF atthe ends of focal adhesions most proximal to the cell nucleus.

Tissue Specificity:
Ubiquitous.

Liprin alpha 1,酪氨酸磷酸酶受体相互作用蛋白Liprin α1抗体Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.

Similarity:
Belongs to the liprin family. Liprin-alpha subfamily.
Contains 3 SAM (sterile alpha motif) domains.

Database links:
Entrez Gene: 8500 Human
Entrez Gene: 233977 Mouse
Entrez Gene: 293645 Rat
Omim: 611054 Human
SwissProt: Q13136 Human
Unigene: 530749 Human
Unigene: 708791 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.