Exendin 4,GLP1类似蛋白Exendin4抗体

产品编号HZ-4121R
英文名称Exendin 4
中文名称GLP1类似蛋白Exendin4抗体
别 名Exendin 4; Exendin4; Exendin-4; EXE4_HELSU .
说 明 书0.1ml 0.2ml
研究领域免疫学 神经生物学 糖尿病
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Gila monster lizard
Exendin 4,GLP1类似蛋白Exendin4抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量4.3kDa
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from Gila monster lizard Exendin 4
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Exendin 4,GLP1类似蛋白Exendin4抗体PubMedPubMed
产品介绍background:
Exendin 4 is a 39 amino acid peptide found in venom from the Gila monster Helicoderma suspectum. It is a member of the glucagon secretin family of peptide hormones and neuropeptides. Exendin 4 is a potent agonist of the GLP1 receptor and hence a potent stimulator of insulin secretion.

Function:
Venom protein that mimics the incretin hormone glucagon-like peptide 1 (GLP-1). It stimulates insulin synthesis and secretion, protects against beta-cell apoptosis in response to different insults, and promotes beta-cell proliferation. It also promotes satiety, reduces food intake, reduces fat deposition, reduces body weight and inhibits gastric emptying. Interacts with GLP-1 receptor (GLP1R). Induces hypotension that is mediated by relaxation of cardiac smooth muscle.

Subcellular Location:
Secreted.

Tissue Specificity:
Expressed by the venom gland.

Similarity:
Belongs to the glucagon family.

Database links:
UniProtKB/Swiss-Prot: P26349.2

Exendin 4,GLP1类似蛋白Exendin4抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Exendin-4是从希拉毒蜥唾液中分离的一种多肽激素,由39个氨基酸残基组成,与胰高血糖素样肽1(GLP-1)有53%的同源性。Exendin-4具有高度的组织特异性,仅在希拉毒蜥的唾液腺中表达, 具有促进葡萄糖依赖性的胰岛素分泌、促进β细胞增殖、减慢胃排空、抑制食物摄取和减轻体重等作用。
肠促胰岛素类似物（exendin-4，Ex-4）是从美洲一种毒蜥的唾液中分泌的胰升糖素样肽-1（glucagon-like peptide-1，GLP-1）类似物，它具有促进胰腺胰岛素的分泌、增加胰岛素敏感性及改善胰岛细胞功能的作用，且不被二肽基肽酶Ⅳ（DPP-Ⅳ）分解，血浆半衰期较长，因而在人类，对糖尿病治疗应用来说是稳定、长效的有治疗前景的药物。
钝尾毒蜥 (Gila monster)