DESCRIPTION
Timentin™ is a 15:1 mixture of ticarcillin and clavulanate. Ticarcillin is a penicillin ß-lactam antibiotic, which is susceptible to ß-lactamase degradation. When combined with clavulanate, a ß-lactamase inhibitor, its efficacy is greatly increased. Timentin™ exhibits high activity against gram-negative bacteria and resistant Agrobacterium species.
Penicillins are a type of β-lactam antibiotic consisting of a four-membered β-lactam ring bound to a five-membered thiazolidine ring. This two-ring system causes distortion of the β-lactam amide bond, resulting in decreased resonance stabilization and increased reactivity. β-lactams inhibit the formation of peptidoglycan cross-links within bacterial cell walls by targeting penicillin-binding proteins or PBPs. Consequently, the bacterial cell wall becomes weak and cytolysis occurs. Resistance to β-lactam antibiotics occurs in the presence of cells containing plasmid encoded extended spectrum β-lactamases or ESBLs.
Antibiotics are often used in clinical in vitro tests known as antimicrobial susceptibility tests or ASTs to determine their efficacy against certain bacterial species. They are tested against gram-negative and gram-positive bacteria using panels, discs, and MIC strips by medical microbiologists. ASTs decrease the risk of using an antibiotic against bacteria exhibiting resistance to it, and the results are used in clinical settings to determine which antibiotic(s) to prescribe for various infections.
Product Specifications
Ticarcillin Disodium 
Potassium Clavulanate
MOLECULAR BIOLOGY GRADE
Formula: C 15H14N2Na2O6S2 / C8H8KNO5
MW: 665.64 g/mol (combined)
Storage/Handling: Store desiccated at -20°C. Soluble in water. 
      植物组培广泛应用于植物科研，如基因工程，模式植物，作物育种等，工厂化生产，如观赏花卉植物，中药材生产，园林园艺等，但是组培过程中种苗的污染是广大工作者最头疼的问题。其中农杆菌是普遍存在于土壤中的一种革兰氏阴性细菌，它能在自然条件下趋化性地感染大多数双子叶植物和裸子植物的受伤部位（受伤处的细胞会分泌大量酚类化合物，从而使农杆菌移向这些细胞），并诱导产生冠瘿瘤或发状根。目前在转基因研究中，使用羧苄、头孢来抑制农杆菌已经不是主流，更多的组培工作者选择效果更好的Timentin产品，中文名称特美汀。
       Timentin(特美汀)是一种新型的有效抑制农杆菌的特效抗生素。抑制农杆菌的同时，对于植物材料的影响很小。特别适合比较难转化的材料的转基因过程，尤其是在农杆菌OD值高，很难被其它抗生素抑制时，效果很好。特美汀在组培实验中常用于抑制农杆菌生长，特别在胚性愈伤组织再生系统中，能达到很好的抑菌和再生效果。
        Timentin其组分为替卡西林钠及克拉维酸钾（Ticarcillin Sodium and Clavulanate Potassium），按有效酸计，替卡西林钠与克拉维酸钾的配比为15:1，替卡西林是青霉素类杀菌剂，而克拉维酸则是一种不可逆性高效β-内酰胺酶抑制剂。多种革兰氏阳性菌（G+）和阴性菌（G-）都能产生β-内酰胺酶，这类酶能在青霉素作用于病原体之前将其破坏。克拉维酸通过阻断β-内酰胺酶破坏细菌的防御屏障，恢复替卡西林敏感性。克拉维酸钾单独抗菌作用甚微，但与替卡西林配置后使本品成为具有广谱杀菌作用的抗生素，适用于能引起尿路感染、骨和关节感染、胃感染和皮肤感染的各种细菌感染有良好的效果。
      替卡西林属于青霉素类。它通过阻止肽聚糖交联抑制细胞壁合成，并最终导致细胞死亡。然而对于β-内酰胺酶是敏感的，所以和克拉维酸钾一起使用，克拉维酸钾能抑制β-内酰胺酶。替卡西林对于抑制革兰氏阴性菌有较好的效果，且和克拉维酸钾结合后能有效抑制农杆菌株。
产品详情链接：http://www.bioconsumable.com/cn/brand/2012/1-6/brand_03942008.htm